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为探讨紫外线对人体皮肤早期损伤的量效特性,在东北地区紫外线不同暴露水平的人群中观察了470人皮肤形态学改变;43人皮肤穿刺样本的组织学、免疫学改变及DNA的变化。结果表明:紫外线对皮肤老化有明显作用,高暴露人群皮肤老化危险性比低暴露人群高1倍,老化发生时间提前10年,皮肤朗罕氏细胞数亦有减少趋势,但未检出P53抑癌基因诱变。
In order to investigate the dose-response characteristics of UV-induced early skin damage, 470 skin morphological changes were observed in the population exposed to ultraviolet light in the Northeast China. The histological, immunological and DNA changes of 43 human skin puncture specimens were observed. The results showed that UV had a significant effect on skin aging. The risk of skin aging in high exposure groups was twice as high as that in low exposure groups. The aging time ten years earlier and the number of Langerhans cells decreased. However, P53 was not detected Oncogenic Mutagenesis.