目的：研究全身热疗对机体的损伤、与热剂量的关系及全身热疗热耐受现象的量化。方法：分别以４０５℃、４１０℃、４１５℃、４２０℃、４２５℃、４３０℃，不同时间对ＮＩＨ小鼠进行加温治疗，观察其死亡情况。热耐受实验以４１５℃２５分钟作为引导加温，然后每隔２４小时按不同温度－时间进行治疗，记录其死亡率。结果：４１５℃、４２℃、４２５℃和４３℃不同加温时间的半数致死时间分别为４０８１ｍｉｎ、２２５２ｍｉｎ、１８２３ｍｉｎ及１３７８ｍｉｎ。热耐受研究证实热疗后２４小时最强，之后每２４小时消减近５０％，但４１５℃２４小时热耐受接近无穷大。４０５℃加热至３小时未见有死亡，４１℃产生最大死亡率为４０％。结论：小鼠全身热疗４１５℃以下约２小时后产生热耐受；２４小时产生最大热耐受，每２４小时约递减５０％。 OBJECTIVE: To study the relationship between body damage, heat dose, and the quantification of thermal tolerance in whole body hyperthermia. METHODS: NIH mice were treated with heating at 405°C, 410°C, 415°C, 420°C, 425°C, 430°C for different periods of time to observe the death. The heat tolerance experiment was conducted at 415°C for 25 minutes as a guide and then every 24 hours for different temperature-time treatments to record the mortality rate. RESULTS: The half-lifetimes at 415°C, 42°C, 425°C and 43°C for different heating time were 4081min, 2252min, 1823min and 1378min, respectively. Thermal tolerance studies confirmed that the hyperthermia was the strongest after 24 hours, followed by a reduction of nearly 50% every 24 hours, but the heat tolerance at 415°C for 24 hours was close to infinity. There was no death at 405°C for 3 hours and 40% for 41°C. CONCLUSIONS: Heat tolerance occurs in mice after whole body hyperthermia for about 2 hours at 415°C; maximum heat tolerance occurs in 24 hours and decreases by approximately 50% every 24 hours.