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目的在常规西医基础之上口服清营汤治疗急性肾损伤,观察清营汤对脓毒症患者肾功能的影响。方法选取确诊脓毒症的患者116例为研究对象,按随机数字表法分为对照组和观察组2组(每组58例),对照组给予常规西医治疗,观察组在常规西医治疗基础上口服清营汤,对2组患者的肾功能情况等进行比较。结果 2组患者治疗后C-反应蛋白(CRP)、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分与治疗前相比差异均有统计学意义(P<0.05),观察组患者治疗后CRP及APACHEⅡ评分与对照组相比差异有统计学意义(P<0.05);2组患者治疗后尿素氮(BUN)及肌酐(Scr)与治疗前相比差异均有统计学意义(P<0.05),观察组患者治疗后BUN及Scr与对照组相比差异有统计学意义(P<0.05);2组患者治疗后胱抑素C(Cys-C)、人中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、肾损伤分子1(KIM-1)与治疗前相比差异均有统计学意义(P<0.05),观察组患者治疗后NGAL、Cys-C及KIM-1与对照组相比差异有统计学意义(P<0.05)。结论在常规西医治疗基础上口服清营汤,CRP、APACHEⅡ、Scr、BUN、NGAL、Cys-C及KIM-1等数值均有明显改善,且优于单纯西医治疗方式,提示口服清营汤能够减轻全身炎症反应,减轻多脏器损害,一定程度上对肾功能起到保护作用。
Objective To observe the effect of Qingying Decoction on renal function in patients with sepsis by oral Qingying Decoction on the basis of routine western medicine. Methods One hundred and sixty-six patients with sepsis were selected as study subjects and divided into control group and observation group (58 cases in each group) according to random number table. The control group was given routine Western medical treatment. The observation group was on the basis of conventional Western medical treatment Oral Qingying Decoction, the renal function of patients in two groups were compared. Results The CRP, APACHE Ⅱ scores of two groups after treatment were significantly different from those before treatment (P <0.05). After treatment, the levels of CRP, Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) (P <0.05). There was significant difference between the two groups in the blood urea nitrogen (BUN) and creatinine (Scr) after treatment (P <0.05) , The observation group patients after treatment BUN and Scr compared with the control group, the difference was statistically significant (P <0.05); two groups of patients after treatment cystatin C (Cys-C), human neutrophil gelatinase-related lipid The levels of NGAL, KIM-1 and KIM-1 were significantly different from those before treatment (P <0.05). NGAL, Cys-C and KIM-1 in the observation group were significantly lower than those in the control group The difference was statistically significant (P <0.05). Conclusions Oral administration of Qingying Decoction on the basis of routine western medicine treatment significantly improved the values of CRP, APACHEⅡ, Scr, BUN, NGAL, Cys-C and KIM-1 and is superior to western medicine treatment alone, suggesting that oral Qingying Decoction can Reduce the systemic inflammatory response, reduce multiple organ damage, to a certain extent, play a protective role on renal function.