使用放射配体结合法检测 Wistar 大鼠肝细咆液糖支质激素受体(GCR)最大结合容量(Ro)和离解常数(Kd),发现糖皮质激素细胞和柴苓汤组 GCR 数目 Ro 明显减少,糖皮质激素加柴苓汤组 Ro 明显高于糖皮质激素组,且各组 Kd 值间无显著差异。提示柴苓汤对 GCR 的调节具有糖皮质激素佯的降调作用,又具有明显的抑制糖之质激素引起的降调作用的双重影响。 Radioligand binding assay was used to detect the maximum binding capacity (Ro) and dissociation constant (Kd) of the glucose-receptor hormone receptor (GCR) in Wistar rats’ liver fine fluids. It was found that the number of GCRs in the glucocorticoid cells and the Chaiqin decoction group was significant. The decrease of Ro was significantly higher in glucocorticoid plus Chaiqin Tang group than in glucocorticoid group, and there was no significant difference among the Kd values ​​in each group. It is suggested that the regulation of GCR by Chaiqin Decoction has a down-regulating effect of glucocorticoid 佯, and it also has the dual effect of inhibiting the down-regulation of glucocorticoids.