S期激酶相关蛋白2(SKP2)是近年来在实体瘤研究中发现的一种癌蛋白,它作为F-box蛋白的一种,能促进癌细胞的细胞周期进展,并存在于多种实体瘤中。之前许多研究报道了其在胃癌、前列腺癌、口腔上皮鳞癌等多种恶性肿瘤中的作用,但在肺癌中的作用还未见报道。本文就SKP2近年来的研究进展及其与肺癌的关系,特别是在肺癌的预后及治疗中的作用作一综述。 S-kinase-related protein 2 (SKP2) is an oncoprotein found in solid tumors in recent years. As an F-box protein, SKP2 promotes the cell cycle progression of cancer cells and exists in many solid tumors . Many studies have previously reported its role in various malignancies such as gastric cancer, prostate cancer and oral squamous cell carcinoma, but its role in lung cancer has not been reported yet. This review summarizes recent advances in SKP2 and its relationship with lung cancer, especially in the prognosis and treatment of lung cancer.