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目的：探讨癌基因蛋白Ｂｃｌ－２在肺癌组织中的表达及意义。方法：采用鼠抗人Ｂｃｌ－２蛋白单克隆抗体，应用免疫组化方法检测肺癌组织抗凋亡基因Ｂｃｌ－２的表达产物。结果：６９例肺癌Ｂｃｌ－２阳性率为３０．４％，其中鳞癌３３．３％（９／２７），腺癌１４．８％（４／２７），大细胞癌０（０／２），小细胞癌６１．５％（８／１３）。小细胞肺癌阳性率明显高于非小细胞肺癌（Ｐ＜０．０５），Ｂｃｌ－２表达与肿瘤大小、Ｔ级别、淋巴结转移、临床分期无关（Ｐ均＞０．０５），与组织分化程度显著相关（Ｐ＜０．０１）。结论：本研究结果表明肺癌的发生及分化程度与抗凋亡基因Ｂｃｌ－２的异常表达有关。
Objective: To investigate the expression and significance of the oncogene protein Bcl-2 in lung cancer. METHODS: Mouse anti-human Bcl-2 protein monoclonal antibody was used to detect the expression product of anti-apoptosis gene Bcl-2 in lung cancer tissues by immunohistochemistry. Results: The positive rate of Bcl-2 was 30.4% in 69 lung cancer cases, including 33.3% (9/27) of squamous cell carcinoma, 14.8% (4/27) of adenocarcinoma, and 0 (0/2) of large cell carcinoma. , Small cell carcinoma 61.5% (8/13). The positive rate of small cell lung cancer was significantly higher than that of non-small cell lung cancer (P<0.05). The expression of Bcl-2 was not related to tumor size, T grade, lymph node metastasis, clinical stage (P>0.05), and the degree of histological differentiation. Significantly related (P<0.01). Conclusion: The results of this study indicate that the occurrence and differentiation of lung cancer is related to the abnormal expression of anti-apoptosis gene Bcl-2.