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目的:通过对外周血CA19-9、CEA的联合检测,了解其对消化道恶性肿瘤诊断的价值及临床意义。方法:采用酶联免疫吸附法对128例消化道恶性肿瘤患者的CA19-9、CEA水平进行测定。结果:肿瘤组CA19-9水平显著高于正常对照组(P<0.05),阳性率:结/直肠癌组16.6%,胃/贲门癌组13.3%。肿瘤组CEA水平显著高于正常对照组(P<0.001)。阳性率:结/直肠癌组52.4%,胃/贲门癌组38.6%。结论:CA19-9和CEA的联合检测,可提高消化道肿瘤诊断的特异性,并对疗效观察、监测肿瘤的转移与复发有实际意义。
OBJECTIVE: To evaluate the value and clinical significance of CA19-9 and CEA in the diagnosis of gastrointestinal malignancies. Methods: The levels of CA19-9 and CEA in 128 patients with gastrointestinal cancer were determined by enzyme-linked immunosorbent assay. Results: The level of CA19-9 in the tumor group was significantly higher than that in the normal control group (P <0.05). The positive rate was 16.6% in the node / rectal cancer group and 13.3% in the gastric / cardiac cancer group. CEA levels in tumor group were significantly higher than those in normal control group (P <0.001). Positive rate: knot / rectal cancer group 52.4%, stomach / cardia cancer group 38.6%. Conclusion: The combined detection of CA19-9 and CEA can improve the specificity of diagnosis of gastrointestinal tumors, and has practical significance for the observation of the curative effect and the monitoring of tumor metastasis and recurrence.