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Coronavirus disease 2019(COVID-19),reminiscent of the severe acute respiratory syndrome(SARS)outbreak in 2003,has been a tragic disaster to people all over the world.As there is no specific drug for COVID-19,neutralizing antibodies are attracting more and more attention as one of the most effective means to combat the pandemic.Here,we introduced the etiological and serological characteristics of COVID-19,discussed the current stage of development of human monoclonal antibodies against SARS-CoV-2 and summarized the antigenic epitopes in the S glycoprotein,which may deepen the understanding of the profile of immune recognition and response against SARS-CoV-2 and provide insight for the design of effective vaccines and antibody-based therapies.