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目的探讨血栓通联合前列地尔对下肢动脉硬化闭塞症(LEASO)患者血清超敏C反应蛋白(hs-CRP)、尿酸(UA)、尿酸盐转运蛋白(UAT)水平变化及对预后的影响,为LEASO患者的治疗提供依据。方法选取2014年3月至2016年12月蛇口人民医院收治的92例LEASO患者作为研究对象,根据不同治疗方案分为联合治疗组和对照组,每组46例。对照组给予前列地尔治疗,联合治疗组在此基础上联合血栓通治疗。对比两组治疗前后血清中hs-CRP、UA、UAT、血流动力学指标[全血黏度、血浆黏度、纤维蛋白原(FIB)]水平及生活质量评分,统计两组临床疗效及不良反应发生率。用SPSS 18.0统计软件进行独立样本t检验、χ2检验和Ridit分析。结果治疗后,联合治疗组显效32例,有效12例,无效2例;对照组显效21例,有效18例,无效7例,联合治疗组治疗效果优于对照组,差异有统计学意义(P<0.05)。两组患者治疗前hs-CRP、UA、UAT水平和血流动力学指标比较,差异均无统计学意义(P>0.05)。治疗后,联合治疗组UAT水平明显高于对照组,hs-CRP、UA水平和血流动力学指标均明显低于对照组,差异均有统计学意义(P<0.01),治疗后,联合治疗组生活质量评分明显高于对照组,差异有统计学意义(P<0.05)。联合治疗组不良反应发生率(8.70%,4/46)与对照组(6.52%,3/46)比较,差异无统计学意义(P>0.05)。结论血栓通联合前列地尔治疗LEASO可有效改善患者血清中hs-CRP、UA、UAT水平及血流动力学指标,临床效果显著,且具有一定安全性,有利于改善患者的生活质量。
Objective To investigate the effects of Xueshuantong combined with alprostadil on the levels of serum hs-CRP, UA and UAT in lower extremity atherosclerosis obliterans (LEASO) and its prognostic value , Provide the basis for the treatment of LEASO patients. Methods From March 2014 to December 2016, 92 patients with LEASO admitted to Shekou People’s Hospital were enrolled in this study. They were divided into combined treatment group and control group with 46 cases in each group. The control group was treated with alprostadil, and the combined treatment group was treated with Xueshuantong on this basis. The levels of serum hs-CRP, UA, UAT, hemodynamics [whole blood viscosity, plasma viscosity, fibrinogen (FIB)] and quality of life were compared between the two groups before and after treatment, and the clinical efficacy and adverse reactions rate. Independent sample t-test, χ2 test and Ridit analysis were performed using SPSS 18.0 statistical software. Results After treatment, the combination therapy group was effective in 32 cases, effective in 12 cases and ineffective in 2 cases. In the control group, 21 cases were markedly effective, 18 cases were effective and 7 cases were ineffective. The treatment effect in the combined treatment group was superior to that in the control group (P <0.05). There was no significant difference in hs-CRP, UA, UAT and hemodynamics between the two groups before treatment (P> 0.05). After treatment, the level of UAT in the combination therapy group was significantly higher than that in the control group, and the levels of hs-CRP, UA and hemodynamics were significantly lower than those in the control group (P <0.01). After treatment, the combination therapy Group quality of life scores were significantly higher than the control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the combination therapy group (8.70%, 4/46) and the control group (6.52%, 3/46) (P> 0.05). Conclusion Xueshuantong combined with alprostadil can effectively improve the levels of hs-CRP, UA, UAT and hemodynamics in patients with LEASO. The clinical effect is significant, and has some safety, which is beneficial to improve the quality of life of patients.