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目的:研究糖皮质激素对嗜酸性粒细胞(Eos)的活化及干扰素-γ(IFN-γ)的影响,探讨嗜酸性粒细胞阳离子蛋白(ECP)、IFN-γ的变化与肺功能状态的相关性,以及ECP与IFN-γ之间的相关性。方法:哮喘患者经糖皮质激素治疗前后对外周血Eos进行计数、并检测血清ECP、IFN-γ的水平及1s用力呼气容积占用力肺活量比值(FEV1%)。结果:(1)哮喘患者经糖皮质激素治疗后,与治疗前相比较,血中EOS值和血清ECP的水平均明显下降(P<0.05,P<0.01);而血清IFN-γ的水平和FEV1%值均明显升高(P<0.05)。(2)ECP水平的下降值与IFN-γ水平的升高呈负相关(r=-0.6532,P<0.05)。(3)IFN-γ水平的升高值与FEV1%值的升高呈正相关(r=0.5246,P<0.05)。结论:经糖皮质激素治疗后,哮喘患者外周血EOS、ECP等炎性指标明显下降,ECP与IFN-γ呈负相关,IFN-γ与FEV1%呈正相关,说明糖皮质激素抑制哮喘炎症反应的机制,可能与血清IFN-γ水平的升高有关,从而抑制哮喘患者Th2优势,起到治疗哮喘的作用。
Objective: To investigate the effects of glucocorticoids on eosinophil (Eos) activation and interferon-γ (IFN-γ), to explore the relationship between eosinophil cationic protein (ECP), IFN-γ and pulmonary function status Correlation, and the correlation between ECP and IFN-γ. Methods: Peripheral blood Eos was counted before and after glucocorticoid treatment in asthmatic patients. Serum levels of ECP and IFN-γ and FEV1% of 1s forced expiratory volume were measured. Results: (1) The levels of EOS and serum ECP in asthmatic patients after glucocorticoid treatment were significantly lower than those before treatment (P <0.05, P <0.01), while the levels of serum IFN-γ and FEV1% values were significantly increased (P <0.05). (2) The decrease of ECP level was negatively correlated with the increase of IFN-γ level (r = -0.6532, P <0.05). (3) The level of IFN-γ was positively correlated with the increase of FEV1% (r = 0.5246, P <0.05). CONCLUSION: Eos, ECP and other inflammatory indexes in peripheral blood of asthmatic patients were significantly decreased after glucocorticoid treatment, and ECP was negatively correlated with IFN-γ, while IFN-γ was positively correlated with FEV1%, indicating that glucocorticoid inhibited the inflammatory response of asthma Mechanism may be related to elevated serum IFN-γ levels, thereby inhibiting the Th2 advantage in asthma patients, play a role in the treatment of asthma.