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目的:观察早期序贯治疗对改善新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)预后的效果。方法:将62例中、重度H IE患儿随机分为干预组(33例)和对照组(29例),在新生儿期接受相同的综合治疗,干预组按鲍氏提出的“0~3岁早期干预大纲”为指导进行个体化的早期序贯治疗。结果:干预组自6月龄始智力发育及运动发育指数较对照组有显著改善,干预组康复率为87.88%,对照组仅为61.51%,差异有统计学意义(P<0.05)。结论:早期序贯治疗能促进H IE患儿的智力及体格发育,减少后遗症的发生。
Objective: To observe the effect of early sequential therapy on the prognosis of hypoxic-ischemic encephalopathy (HIE). Methods: Sixty-two children with moderate and severe HIE were randomly divided into intervention group (n = 33) and control group (n = 29). The same comprehensive treatment was performed in neonatal period. According to the “ 3-year-old early intervention program ”to guide the individualized early sequential treatment. Results: The mental development and motor development index of the intervention group were significantly improved from the 6th month. The recovery rate was 87.88% in the intervention group and 61.51% in the control group, the difference was statistically significant (P <0.05). Conclusion: Early sequential therapy can promote intelligence and physical development of HIE children and reduce the occurrence of sequelae.