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目的探讨盐酸帕罗西汀片治疗老年非糜烂性胃食管反流病的临床疗效及对患者生活质量的影响。方法选取武义县中医院110例非糜烂性胃食管反流病患者为研究对象,随机分为两组,每组各55例。对照组患者给予埃索美拉唑肠溶片与多潘立酮片联合治疗。观察组患者在对照组治疗方式基础上给予盐酸帕罗西汀片治疗,比较两组临床疗效及患者治疗前后生活质量指标。结果观察组患者的总有效率96.4%高于对照组总有效率74.5%,差异有统计学意义(χ2=10.53,P<0.01)。治疗后,观察组患者的SCL-90、SRSS、SDS、SAS、GERD-HRQL、RDQ自评评分均显著优于对照组,差异有统计学意义(P<0.01)。对照组患者复发率显著高于观察组,差异有统计学意义(P<0.01)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论盐酸帕罗西汀片治疗非糜烂性胃食管反流病疗效确切,可以显著提高患者生活质量,临床应用价值显著。
Objective To investigate the clinical efficacy of paroxetine hydrochloride tablets in the treatment of geriatric non-erosive gastroesophageal reflux disease and its impact on quality of life. Methods A total of 110 patients with non-erosive gastroesophageal reflux disease in Wuyi Hospital of Traditional Chinese Medicine were selected as study subjects and randomly divided into two groups of 55 cases each. Patients in the control group were treated with esomeprazole enteric-coated tablets and domperidone tablets. Patients in the observation group were treated with paroxetine hydrochloride tablets on the basis of the control group, and the clinical efficacy and quality of life before and after treatment were compared between the two groups. Results The total effective rate in observation group was 96.4% higher than that in control group (74.5%), the difference was statistically significant (χ2 = 10.53, P <0.01). After treatment, the scores of SCL-90, SRSS, SDS, SAS, GERD-HRQL and RDQ in the observation group were significantly better than those in the control group (P <0.01). The recurrence rate of the control group was significantly higher than that of the observation group, the difference was statistically significant (P <0.01). Adverse reactions between the two groups, the difference was not statistically significant (P> 0.05). Conclusion Paroxetine hydrochloride tablets in the treatment of non-erosive gastroesophageal reflux disease is effective and can significantly improve the quality of life of patients with significant clinical value.