This study deals with the relationship between sea-level changes and paleoclimatic fluctuations based on the analysis of stratigraphy, grain sizes, palynology, and radiometric dating of the Yellow River delta since the Late Pleistocene. Evidence from the sedimentary record, grain sizes, and pollen provides a paleoenvironmental history of the Late Pleistocene from the boreholes of the delta. Based on a combination of grain-size analysis with lithological studies, marine deposit units contain the intervals of 13.85–16.9, 18.5–19.69, 27.9–34.8, 36.4–37.2, 48.4–51.6, and 54.1–55.9 m, and transitional facies units contain the intervals of 10.25–13.85, 16.9–18.5, 19.69–27.9, 34.8–36.4, 37.2–48.4, 51.6–54.1, and 55.9–60 m, compared with fluvial (terrestrial facies) deposit units (3.36–10.25 m). Based on pollen analysis and pollen assemblages, there were three warm-wet periods from 9.1–0.16 ka BP, 16.1–60 ka BP, and 90.1–94.6 ka BP From the top to the bottom of the borehole, the paleoclimate has an evident fluctuation: warm and moist (Holocene Optimum) —cool and dry (Younger Dryas Event)—mild semi cool—cool and dry—warm and moist. There were three warm-wet periods from 9.1–0.16 ka BP, 16.1–60 ka BP, and 90.1–94.6 ka BP, corresponding to the Holocene Optimum stage, MIS 3, and MIS 5, respectively. The warm period allowed monsoonal evergreen and broadleaved deciduous forests that corresponded to Holocene hypsithermal climatic conditions and the Late Pleistocene climatic Optimum. Three warm-wet periods occurred in marine deposit units from 9.1–0.16 ka BP, 60.1–16.1 ka BP, and 94.6–90.1 ka BP. These periods correspond to the Cangzhou transgression, Xianxian transgression, and Huanghua transgression, respectively. From 90.1–60.1 ka BP, 17.5–9.1 ka BP, and 0. 16 ka BP–1855 AD, three dry and cold phases are recognized. The phases indicate the fluvial (flood plain) sedimentary environment, corresponding to cooler and mild dry periods based on palynological results and grain-size distribution.