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答:奋乃静和氟奋乃静都是吩噻嗪的衍生物,是临床治疗精神病或精神症状的强安定药,小剂量应用对头晕、恶心、呕吐等也有一定疗效。但这一类药物都有较明显的付作用,最常见的付作用是神经系统运动功能的失调,表现为:(1)震颤麻痹:动作迟钝、面部表情少、手指震颤、慌张步态等;(2)运动不调与肌张力失调:如斜颈、抽搐、面部表情异常、眼球旋动等;(3)不能静坐,坐立不安等。这一类药物的作用常因化学结构改变而不相同,在吩噻嗪主环上加上侧链作用增强,付作用也大,尤其是卤素越多,付作用也越明显。奋乃静的侧链是 C1,而氟奋乃静则是CF_3,因此氟奋乃静就比奋乃静更易于发生种种付作用。根据我们的实践体会,某些病员内服氟奋乃静以
A: Perphenazine and fluphenazine are phenothiazine derivatives, is a clinical treatment of psychiatric or psychiatric symptoms of strong stability drugs, low-dose applications of dizziness, nausea, vomiting, etc. also have a certain effect. However, this type of drugs have a more obvious role in payment, the most common role in the payment of nervous system dysfunction of motor function, manifested as: (1) Parkinsonism paralysis: slow movements, facial expressions, finger tremor, panic gait; (2) exercise disorders and dystonia: such as torticollis, convulsions, facial expression abnormalities, eye rotation, etc .; (3) can not sit, restless and so on. The role of this class of drugs often due to changes in chemical structure are not the same, in the phenothiazine main ring plus the role of side chain enhancement, the role is also large, especially the more halogen, pay the more obvious. Perphenazine side chain is C1, and fluphenazine is CF_3, so fluphenazine than perphenazine is more prone to pay for all kinds of role. According to our practice experience, some patients orally take fluphenazine to