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丝氨酸是制造抗结核菌的环丝氨酸(Cycloserine)及抗癌药物,二氯乙酰丝氨酸(N-dichloroacetyl-DL-serine)及许多生物化学制品的原料,也是生化研究,特别是蛋白质研究用的标准氨基酸之一。 丝氨酸的制备法很多,但其主要药品既昂贵又不易获得。本法采用工业废品,即蓖麻蚕丝的茧衣或丝胶为原料;用国产最便宜的磺化煤为离子交换剂做层析柱;用无机溶剂,即水及盐酸为洗脱剂。并且,其操作可以在室温下进行,因此免去了加温的麻烦。而其回收率可达80％左右。如果用家蚕丝胶为原料,可能更为有利,因为其中丝氨酸含量此蓖麻蚕的还高。
Serine is the raw material for the manufacture of anti-tuberculosis Cycloserine and anti-cancer drugs, N-dichloroacetyl-DL-serine and many biochemical products. It is also the standard amino acid for biochemical research, especially for protein research one. There are many ways to prepare serine, but its major drugs are both expensive and not readily available. This method uses industrial waste, that is, ricin silk cocoon clothing or sericin as raw material; made with the cheapest domestic sulfonated coal as ion exchanger column; with inorganic solvents, namely water and hydrochloric acid as eluent. And, its operation can be carried out at room temperature, thus eliminating the hassle of the trouble. The recovery rate of up to 80%. If you use silk sericin as raw material, may be more favorable, because of serine content of this castor silkworm is also high.