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目的:探讨利尿剂联合ARB治疗肾病综合征合并高血压的临床疗效。方法:选取我院收治的96例肾病综合征合并高血压患者,以治疗方式的不同将其分观察组、治疗组及对照组三组,每组32例,观察组患者行利尿剂联合ARB治疗,治疗组行单纯ARB(血管紧张素Ⅱ受体拮抗剂)治疗,对照组行单纯利尿剂治疗,并对三组患者治疗前后的血压、尿蛋白排泄率及肾功能进行比较。结果:三组患者治疗后血压、尿蛋白排泄率、尿素氮、血肌酐均有明显改善,相当对于治疗前有明显差异(P<0.05);观察组患者的血压及尿素氮、血肌酐改善情况均明显优于对照组及治疗组患者(P<0.05);治疗组患者及观察组患者的尿蛋白排泄率均明显优于对照组(P<0.05)。结论:肾病综合征合并高血压患者采用利尿剂联合ARB治疗其效果明显优于单独用药,临床效果显著,值得推广和应用。
Objective: To investigate the clinical efficacy of diuretic combined with ARB in the treatment of nephrotic syndrome complicated with hypertension. Methods: A total of 96 patients with nephrotic syndrome complicated with hypertension were enrolled in our hospital. 32 patients in each group were divided into observation group, treatment group and control group with different treatment methods. Patients in observation group were treated with diuretic combined with ARB , The treatment group was treated with ARB (angiotensin Ⅱ receptor antagonist), the control group was treated with diuretic alone, and the blood pressure, urinary protein excretion rate and renal function were compared between the three groups before and after treatment. Results: After treatment, blood pressure, urinary protein excretion rate, urea nitrogen and serum creatinine were significantly improved in all three groups, which were quite different from those before treatment (P <0.05). Blood pressure, urea nitrogen and serum creatinine were improved in the three groups (P <0.05). Urinary protein excretion rate in treatment group and observation group were significantly better than that in control group (P <0.05). Conclusion: Nephrotic syndrome patients with hypertension and diuretic combined with ARB treatment was significantly better than the single drug, the clinical effect is significant, it is worth promoting and application.