自1941年Huggins和Hodges发现前列腺癌的雄激素依赖性,并采用内分泌治疗以来,雄激素去除治疗(androgen deprivation therapy,ADT)被广泛地用于前列腺癌的非手术治疗中。而当ADT治疗成功用于控制前列腺癌病程的同时,人们对它可能导致的骨质疏松却未能引起足够的重视。许多晚期前列腺癌患者在ADT过程中出现了骨代谢异常,甚至出 Androgen deprivation therapy (ADT) has been widely used in the non-surgical treatment of prostate cancer since Huggins and Hodges discovered the androgen dependence of prostate cancer in 1941 and used endocrine therapy. When ADT treatment is successfully used to control the course of prostate cancer, people may not pay enough attention to the osteoporosis that it may cause. Many patients with advanced prostate cancer in the process of ADT appeared abnormal bone metabolism, and even out