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To evaluate whether the chemosensitivity of primary central nervous system ly mphomas to water soluble drugs could result from improved drug delivery, we qu antitatively assessed pharmacokinetic factors in seven patients. The capillary p ermeability surface product was found to be significantly increased in central n ervous system lymphomas compared with glioblastoma multiforme, medulloblastomas, and metastases. Tumoral blood flow was significantly greater than in normal whi te matter. Our results suggest favorable pharmacokinetics to water and lipid soluble drugs in primary central nervous system lymphomas.
To evaluate the the chemosensitivity of primary central nervous system ly mphomas to water-soluble drugs could result from improved drug delivery, we qu antitatively assessed pharmacokinetic factors in seven patients. The capillary p ermeability surface product was found to be significantly increased in central n ervous system lymphomas compared with glioblastoma multiforme, medulloblastomas, and metastases. Tumoral blood flow was significantly greater than in normal whi te matter. Our results suggest favorable pharmacokinetics to water- and lipid-soluble drugs in primary central nervous system lymphomas.