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采用丹酰氯－聚酰胺薄层层析法定量检测６０例急性淋巴细胞白血病患儿红细胞内多胺水平改变。结果显示：（１）急性淋巴细胞白血病患儿红细胞多胺水平高于正常组，并且以精脒和精脒／精胺比值的变化最为显著（Ｐ＜０．００１）。（２）急性淋巴细胞白血病经治疗缓解后，红细胞多胺水平均有不同程度下降，其中以精脒下降幅度较大（Ｐ＜０．００１），但仍高于正常组（Ｐ＜０．００１），而精脒／精胺比值也下降，低于疗前组（Ｐ＜０．０５），但高于正常组（Ｐ＜０．０５）。结果提示急性淋巴细胞白血病患儿红细胞多胺的检测有助于白血病诊断、观察疗效和评估预后。
Dansyl chloride - polyamide thin layer chromatography quantitative detection of 60 cases of acute lymphoblastic leukemia in children with polyamine level changes. The results showed that: (1) The level of erythrocyte polyamine in children with acute lymphoblastic leukemia was higher than that in normal group, and the ratio of spermidine to spermidine / spermine was the most significant (P <0.001). (2) After the treatment of acute lymphoblastic leukemia, the levels of erythrocyte polyamines decreased to some extent, among them, spermidine decreased significantly (P <0.001), but still higher than the normal group (P <0.001) ), And spermidine / spermine ratio also decreased, lower than the pre-treatment group (P <0.05), but higher than the normal group (P <0.05). The results suggest that detection of erythrocyte polyamines in children with acute lymphoblastic leukemia contributes to the diagnosis of leukemia, to observe the curative effect and evaluate the prognosis.