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目的探讨中老年人颈总动脉平均内膜中层厚度(IMT)和血尿酸水平的相关性。方法应用彩色多普勒超声检测104例中老年人颈总动脉平均IMT、同时行血尿酸检查,按血尿酸水平分为尿酸正常组、高尿酸血症组,分析血尿酸与颈动脉内膜中层厚度的相关性。结果高血压、颈动脉内膜厚度、胆固醇、HDL-C及Apo-a均有统计学意义(P<0.05),即高尿酸血症组高血压、颈动脉内膜厚度及胆固醇明显高于尿酸正常组(P<0.05),但HDL-C及Apo-a明显低于尿酸正常组(P<0.05)。结论高尿酸血症组高血压患者明显增加,颈总动脉内膜中层厚度增加,胆固醇水平有意义地增高,相反高密度脂蛋白和载脂蛋白a明显降低,血尿酸可能是动脉粥样硬化的早期标记。
Objective To investigate the correlation between carotid artery mean intima-media thickness (IMT) and serum uric acid level in middle-aged and elderly people. Methods The average IMT of common carotid arteries of 104 middle-aged and old people was detected by color Doppler ultrasonography. At the same time, the blood uric acid was examined. The level of serum uric acid was divided into normal uric acid group and hyperuricemia group. Thickness of the correlation. Results Hypertension, carotid intima-media thickness, cholesterol, HDL-C and Apo-a were all statistically significant (P <0.05) .Hypertension, carotid intima-media thickness and cholesterol in hyperuricemia group were significantly higher than uric acid Normal group (P <0.05), but HDL-C and Apo-a were significantly lower than those in normal uric acid group (P <0.05). Conclusion Hyperuricemia patients with hypertension increased significantly, the carotid artery intima-media thickness increased, cholesterol levels increased significantly, while high-density lipoprotein and apolipoprotein a decreased significantly, serum uric acid may be atherosclerosis Early mark.