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目的探讨胃癌组织中CD25表达及作用。方法 122例存档石蜡包埋胃癌组织,依据组织分化程度分为中高分化腺癌组(腺癌1、2级和乳头状腺癌,45例)和低分化腺癌组(腺癌3级和黏液腺癌,77例)。应用免疫组织化学(SP)法检测两组CD25蛋白的表达及分布。结果 CD25蛋白在胃癌中的表达率为19.7%(24/122);中高分化腺癌组中CD25蛋白的表达(31.1%)高于低分化腺癌组(13.0%),差异有统计学意义(χ~2=5.9,P=0.015<0.05);未发现CD25的表达与患者性别、年龄、肿瘤直径、淋巴转移、T分期和TNM分期等相关(P>0.05)。结论胃癌组织中存在不同程度CD25蛋白表达,其表达与组织分化存在一定相关性,提示CD25蛋白可能在某种程度上参与胃癌发生发展,是胃癌预后不良的因素和潜在治疗靶点。
Objective To investigate the expression of CD25 in gastric cancer and its role. Methods 122 cases of paraffin-embedded gastric cancer tissues were divided into moderate-high differentiated adenocarcinoma group (adenocarcinoma grade 1 and 2 and papillary adenocarcinoma, 45 cases) and poorly differentiated adenocarcinoma group (adenocarcinoma grade 3 and mucus Adenocarcinoma, 77 cases). Immunohistochemistry (SP) was used to detect the expression and distribution of CD25 protein in two groups. Results The positive rate of CD25 protein in gastric carcinoma was 19.7% (24/122). The expression of CD25 protein in moderately well-differentiated adenocarcinoma was higher than that in poorly differentiated adenocarcinoma (31.1%) (31.1%), the difference was statistically significant ( χ ~ 2 = 5.9, P = 0.015 <0.05). No correlation was found between the expression of CD25 and the gender, age, tumor diameter, lymph node metastasis, T stage and TNM stage (P> 0.05). Conclusions The expression of CD25 protein in gastric cancer tissues is different, and the expression of CD25 is correlated with tissue differentiation. The results suggest that CD25 may be involved in the development of gastric carcinoma to a certain extent. It is a potential prognostic factor and a potential therapeutic target for gastric cancer.