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报告了194名幼儿、44名成人接种乙肝疫苗后的效果,分别于首次接种后10、13、19个月观察HBsAg,抗-HBs、抗-HBc的应答情况,结果幼儿累计抗-HBs阳性率为78.9％(459/582),成人为81.62％(36/44),对照组(未接种幼儿)为6.00％(3/50),幼儿接种组与对照组比较有高度显著差异(P<0.01),与成人接种组比较无显著差异(P>0.05)。抗-HBs滴度分布,无论幼儿和成人接种疫苗后绝大多数呈低、中度反应;弱、高度反应的甚少,而对照组无中、高度抗体反应,弱、低度反应的也仅为4.00％。无论是抗-HBs抗体应答率,还是滴度分布,男女无差异。结果还表明,国产乙肝疫苗(上海,北京生产)在不同人群中应用均可获得满意的效果。
The results of 194 young children and 44 adults on hepatitis B vaccination were reported. The response of HBsAg, anti-HBs and anti-HBc were observed at 10, 13 and 19 months after the first vaccination, respectively. Results The cumulative positive rate of anti-HBs (78.9%, 459/582), 81.62% (36/44) in adults and 6.00% (3/50) in control group (P <0.01), and there was a significant difference between control group and inoculation group ), No significant difference compared with adult vaccinated group (P> 0.05). The distribution of anti-HBs titer showed that most of the patients showed low and moderate responses after vaccination, weak and highly reactive ones, while the control group had no moderate and high antibody responses and weak and low responses 4.00%. Whether anti-HBs antibody response rate, or titer distribution, no difference between men and women. The results also show that domestic hepatitis B vaccine (Shanghai, Beijing production) can be obtained in different populations satisfactory results.