附子生品毒性较大,其中的乌头类双酯型生物碱既是主要毒性成分,也是附子抗炎镇痛作用的主要有效成分[1]。目前文献中多是对乌头碱单体毒性的报道,尚无生附子总生物碱提取物毒性的研究报道,我们进行了总碱提取物的急性毒性实验。1材料1·1动物清洁级ICR小鼠,体重18~20 g,雌雄各 Aconite products toxicity, aconite diester alkaloids which are both the main toxic components, but also aconite anti-inflammatory analgesic effect of the main active ingredient [1]. At present, most reports on the toxicity of aconitine are still reported in the literatures. There is no report about the toxicity of total alkaloid extract of Aconitum nigrum, and we conducted the acute toxicity experiment of total alkaloid extract. 1 Materials 1.1 animal clean ICR mice, weighing 18 ~ 20 g, male and female each