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卵巢早衰在临床上主要表现为促性腺激素水平升高、闭经及不孕,严重影响了女性的生殖健康,近年来其发病率呈上升趋势。目前卵巢早衰的发病原因和发病机制尚不清楚。微小RNA(micro RNA,mi RNA)是近年来发现的一种转录后调节因子,在细胞增殖、分化和凋亡等过程中起重要作用。卵巢中存在的mi RNA通过对靶基因的调控可以影响卵巢功能,并参与卵巢早衰的发病。对卵巢早衰发病原因及机制的研究,可以为今后早期预测这一疾病的发生并进行早期干预提供理论基础。本文复习相关文献,对mi RNA在卵巢早衰发病中的研究进展进行综述。
Premature ovarian failure in clinical manifestations of elevated levels of gonadotropin, amenorrhea and infertility, seriously affecting the reproductive health of women, its incidence in recent years, an upward trend. The pathogenesis and pathogenesis of premature ovarian failure is not yet clear. Micro RNA (mi RNA) is a post-transcriptional regulator found in recent years and plays an important role in cell proliferation, differentiation and apoptosis. The miRNA present in the ovary affects ovarian function by regulating the target gene and is involved in the pathogenesis of premature ovarian failure. The pathogenesis and mechanism of premature ovarian failure can provide a theoretical basis for the early prediction of the occurrence of this disease and early intervention. This review of relevant literature, the progress of miRNA in the pathogenesis of premature ovarian failure are reviewed.