论文部分内容阅读
[目的]综合评估视黄醇结合蛋白(RBP)水平与非酒精性脂肪肝(NAFLD)的关系.[方法]计算机检索PubMed、Web of Science、Cochrane图书馆、中国知网、中国生物医学文献数据库、维普期刊资源整合服务平台和万方数据知识服务平台,收集有关血清 RBP水平与 NAFLD关系的病例对照研究,检索时限为从各数据库建库至 2017 年 12 月.由 2 名研究人员独立提取资料并评价纳入文献的质量,采用 RevMan 5.3 软件进行 Meta分析.[结果]共纳入 14篇文献,NAFLD患者(观察组)血清 RBP水平高于非 NAFLD患者,即对照组患者(SMD＝0.96,95%CI:0.63～1.28,P ＜0.05).亚组分析显示,合并 2 型糖尿病的患者中观察组的RBP水平高于对照组(SMD＝0.70,95%CI:0.42～0.97,P ＜0.001);≥18岁患者 RBP水平高于对照组(SMD＝0.82,95%CI:0.55～1.09,P ＜0.001),而年龄＜18岁患者的RBP水平与对照组差异无统计学意义(SMD＝1.68,95%CI:－0.22～3.59,P ＝0.08).敏感性分析与发表偏倚分析表明研究结果稳定、无明显发表偏倚.[结论]18岁以上成人 NAFLD患者血清 RBP水平高于非 NAFLD者.“,”[Objective]To evaluate the association between retinol binding protein (RBP)and non-alcoholic fatty liver disease (NAFLD).[Methods]A document retrieval was conducted by retrieval systems,including PubMed,Web of Science,Cochrane Library,Chinese National Knowledge Infrastructure(CNKI),CBM,VIP and Wan Fang Database,to collect the published papers of case-control studies on the theme of association be-tween serum RBP and NAFLD up to Dec.2017.Data collection and quality assessment were performed by two authors,respectively.All the meta-analysis were conducted with software RevMan 5.3.[Results]A total of 14 qualified studies were included in the meta-analysis.The analysis showed that serum RBP might be significantly higher in patients with NAFLD than non-NAFLD patients (SMD＝0.96,95%CI:0.63～1.28,P ＜0.05).Clinical subtype specific subgroup analysis showed that RBP might be higher in patients with type 2 diabetes mellitus and NAFLD than non-NAFLD patients (SMD＝0.70,95%CI:0.42～0.97,P ＜0.001).Age specific subgroup analysis showed the RBP might be higher in patient aged ≥18y than the control (SMD＝0.82,95%CI:0.55～1.09,P ＜0.001),while difference between patient and control aged ＜18y were insignificant (SMD＝1.68,95%CI:－0.22～3.59,P＝0.08).Sensitivity and publication bias analyses indicated that our results were stable and without obvious publication bias.[Conclusion]The meta-analysis shows that serum RBP might be higher in patients aged ≥18y with NAFLD than non-NAFLD patients.