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目的 探讨载脂蛋白E基因 (ApoE)多态性与脑梗死的关系。 方法 采用病例 对照研究 ,对379例脑梗死患者和 35 1例对照组进行研究。采用聚合酶链式反应 限制性片段长度多态性方法测定ApoE基因多态性。结果 脑梗死组ApoE基因型频率E3/3、E3/4、E3/2、E2 /4和E4 /4型分别为72 .3%、14 .5 %、11.6 %、0 .8%、0 .8%。在脑梗死组中未发现E2 /2。E2 /2在脑梗死组和对照组之间有显著性差异 (P <0 .0 5。)结论 ApoE2 /2对脑梗死可能具有保护作用
Objective To investigate the relationship between apolipoprotein E gene (ApoE) polymorphism and cerebral infarction. Methods A case-control study was conducted in 379 patients with cerebral infarction and 351 controls. Polymerase chain reaction restriction fragment length polymorphism was used to determine the ApoE gene polymorphism. Results The frequencies of ApoE genotypes of E3 / 3, E3 / 4, E3 / 2, E2 / 4 and E4 / 4 in cerebral infarction group were 72.3%, 14.5%, 11.6%, 0.8% 8%. E2 / 2 was not found in the cerebral infarction group. E2 / 2 in the cerebral infarction group and the control group were significantly different (P <0.05) Conclusion ApoE2 / 2 may have a protective effect on cerebral infarction