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目的 比较国产恩丹西酮和枢复宁预防白血病化疗消化道反应的疗效。方法 10例能坚持化疗的小儿白血病 ,接受 80个疗程的化疗及 10 0次鞘注 ,各使用国产恩丹西酮和枢复宁预防消化道反应 130例次 ,比较两者的疗效及副作用。结果 国产恩丹西酮和枢复宁预防白血病化疗呕吐的有效率分别是 94.6 2 %和 96 .15 % ,预防恶心的有效率分别是 85 .4%和 86 .9% ,两者有效率无显著性差异 ,两者均无延迟呕吐现象 ,无明显副作用。结论 国产恩丹西酮能有效预防白血病化疗的消化道反应 ,疗效同枢复宁类似
Objective To compare the efficacy of domestic ondansetron and thalidomide in the prevention of gastrointestinal reactions by leukemia chemotherapy. Methods Ten cases of adolescent leukemia who persevered in chemotherapy were enrolled in this study. Eighty courses of chemotherapy and 10 times of intrathecal injection were enrolled in this study. Domestic ondansetron and shifangning were used to prevent 130 cases of digestive tract reactions. The curative effects and side effects of the two methods were compared. Results Domestic ondansetron and sevoflurane in the prevention of leukemia chemotherapy vomiting were 94.62% and 96.15% respectively, the effective rate of prevention of nausea were 85.4% and 86.9%, respectively, the effective rate was Significant differences, both no delayed vomiting, no obvious side effects. Conclusion Domestic ondansetron can effectively prevent the gastrointestinal reaction of leukemia chemotherapy, the curative effect is similar to the same