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采用流式细胞仪对４例急性巨核细胞白血病的抗原分布和巨核细胞ＤＮＡ的倍体性进行了分析，发现血小板恃异性抗原分布在各个病例间有一定差异，其中一例高达８５％以上，ＨＬＡ－ＤＲ￣＋，和细胞在各个病例间分布同样有一定差异，说明白血病巨核细胞系恶性克隆可发生在造血于细胞向巨核细胞分化的不同阶段，病态巨核细胞ＤＮＡ倍性分布大部分处２Ｎ，少部分处于４Ｎ，未见高于４Ｎ巨核细胞。提示其ＤＮＡ倍体化过程受阻。细胞处于Ｓ期和Ｇ＿２＋Ｍ期的细胞＜２０％，白血病细胞的细胞周期分布与正常骨髓细胞相同，超微结构显示白血病细胞有凋亡现象，提示白血病巨核细胞堆积可能与其凋亡减少有关。
Flow cytometry was used to analyze the antigen distribution of 4 cases of acute megakaryocytic leukemia and the ploidy of megakaryocyte DNA. It was found that there were some differences in the distribution of platelet and sputum antigen in each case. One case was as high as 85%. HLA- DR ~ +, and the distribution of cells in each case also have some differences, indicating that leukemia megakaryocyte cell line malignant clones can occur in the hematopoietic differentiation of cells to megakaryocyte different stages, the majority of DNA ploidy distribution of diseased megakaryocytes 2N, less Partially at 4N, no more than 4N megakaryocytes were seen. It suggests that its DNA ploidy process is blocked. The cells in the S phase and G_2+M phase were <20%. The cell cycle distribution of leukemia cells was the same as that of normal bone marrow cells. The ultrastructure showed that the leukemia cells had apoptosis, suggesting that the accumulation of leukemic megakaryocytes might be related to the decrease of apoptosis.