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目的：探索一条新的、更迅速和有效地建立门脉高压和肝纤维化动物模型的途径。材料和方法：采取前瞻性研究方法，在15只大耳白兔通过门静脉主干注入不同稀释度的白芨混悬液，栓塞门静脉末梢血管而升高门脉压，术后3～4周采取同法复查测量门脉压，作肝活检病理切片及血管铸形。结果：通过兔门静脉注入0．4％白芨混悬液4ml，能使门脉压升高约40％，3周后门脉压仍维持较高水平，病理切片示被白芨栓塞部位出现典型的肝纤维化改变，血管铸形见被白芨栓塞的末梢血管约占全肝末梢血管容积的20％．结论：本法操作简便，效果理想，重复性好，药物价格低廉，较其它建立门脉高压动物模型的方法更优越和可靠，有着广泛应用的价值。
OBJECTIVE: To explore a new, more rapid and effective way to establish animal models of portal hypertension and liver fibrosis. MATERIALS AND METHODS: A prospective study was conducted in 15 large white rabbits by injecting different doses of white suspension into the trunk of the portal vein to embolize the peripheral blood vessels of the portal vein to elevate the portal pressure. After 3 to 4 weeks, Review the measurement of portal pressure for liver biopsy and vascular cast. Results: The portal vein pressure was increased by about 40% by injecting 4ml suspension of 0.4% white rabbit into the rabbit’s portal vein. After 3 weeks, the portal pressure was maintained at a high level. Pathological examination showed typical liver Fibrosis, vascular cast to see the capillaries embolized by the capillaries about 20% of the total peripheral blood vessels. Conclusion: The method is simple, effective, reproducible and inexpensive. It is more superior and reliable than other methods for establishing portal hypertension animal models and has wide application value.