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以全氟辛烷磺酸(perfluorooctane sulfonate,PFOS)和全氟辛酸(perfluorooctanoic acid,PFOA)为代表的全氟化合物(perfluorinated compounds,PFCs)广泛应用于工业生产和生活消费等各个领域。但随之而来的环境污染、人群暴露和健康危害也备受关注。目前关于全氟化合物的人群暴露以及健康效应研究已成为研究热点,该文综述了全氟化合物人群暴露状况研究以及毒性效应研究,分析了全氟化合物在血液、母乳等人体基质中的暴露水平及其对肝脏、免疫系统、内分泌系统、生殖系统和婴幼儿发育的毒性效应,并提出全氟化合物对婴幼儿及儿童的生长、发育可能存在重要影响,应将婴幼儿及儿童的PFCs暴露与健康的关系作为未来的研究重点。
Perfluorinated compounds (PFCs) such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are widely used in various fields such as industrial production and living consumption. However, the ensuing environmental pollution, population exposure and health hazards are also of concern. At present, studies on population exposure and health effects of perfluorinated compounds have become the research hotspots. This paper reviews the studies on the exposure of perfluorinated compounds to humans and the toxic effects, and analyzes the exposure levels of perfluorinated compounds in human, such as blood and breast milk, Its toxic effects on the development of liver, immune system, endocrine system, reproductive system and infants and toddlers. It also suggests that perfluorinated compounds may have important influence on the growth and development of infants and children, and should expose and infiltrate PFCs in infants and children The relationship between the future as the focus of research.