11α-羟基-16α、17α-环氧-△~4-孕甾烯-3,20-二酮(Ⅱ)是合成可的松、强的松、肤轻松等甾体激素药物的重要中间体,由16α,17α-环氧-△~4-孕甾烯-3,20-二酮(Ⅰ)经霉菌氧化而得。上海工业微生物研究所从400余株野生梨的霉菌中,选出一株根霉80322新菌株,可在2％底物投料浓度,37℃发酵36～48h,使转化率达到55％以上,其主要发酵产物除11α-羟基-16 11α-hydroxy-16α, 17α-epoxy-△ ~ 4-pregnen-3,20-dione (Ⅱ) is an important intermediate for the synthesis of corticosteroids such as cortisone, prednisone, From 16α, 17α-epoxy - △ ~ 4-pregnen-3,20-dione (Ⅰ) derived from the mold oxidation. Shanghai Institute of Industrial Microbiology from more than 400 strains of wild pear mold, selected a new strain of strain Rhizopus 80322, at 2% substrate concentration, 37 ℃ fermentation 36 ~ 48h, so that the conversion rate of 55% or more, the The main fermentation products except 11α-hydroxy-16