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患者男性,62岁。1989年12日23日行结肠癌切除术,术后放疗5周,未作化疗。1991年7月8日首次发现BUN 8.9mmol/L,Scr 147.6umol/L,尿常规(一)。同年7月30日BUN 12,4mmol/L,Scr 212.2μm01/L。8月3日因直肠癌复发、肝转移而行化疗,应用MCCNU(甲环已亚硝脲)120mg口服,5-氟尿嘧啶(5FU)500mg静注,四氢叶酸钙200mg静注。用药一次迅速出现腰剧烈胀痛、恶心、呕吐,少尿(300ml/日左右),发热,乏力,血压升高(21.3～23.9/13.3～14.6kPa),浮肿,昏睡。BUN 19.6mmol/L,Scr 839.4μmol/L,尿常规(一),以后发生无尿,肾功能进行性恶化,进入终末期尿毒症,行维持性血液透析治疗。
Male patient, 62 years old. Colonoscopy was performed on the 12th, December 23, 1989. The patients were treated with radiotherapy for 5 weeks without chemotherapy. July 8, 1991 for the first time found BUN 8.9mmol / L, Scr 147.6umol / L, urine routine (a). July 30 the same year BUN 12,4mmol / L, Scr 212.2μm01 / L. August 3 due to recurrence of rectal cancer, liver metastasis and chemotherapy, the application of MCCNU (A ring nitrosourea 120mg orally, 5-fluorouracil (5FU) 500mg intravenous infusion of calcium folinate 200mg intravenously. A sharp increase in pain quickly waist pain, nausea, vomiting, oliguria (300ml / day or so), fever, fatigue, elevated blood pressure (21.3 ~ 23.9 / 13.3 ~ 14.6kPa), edema, lethargy. BUN 19.6mmol / L, Scr 839.4μmol / L, urine routine (a), followed by anuria, progressive deterioration of renal function, into the terminal uremia, maintenance hemodialysis treatment.