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总淋巴照射(TLI)作为一种免疫抑制治疗方法通常应用于免疫性疾患及器官移植病人.作者采用TLI 治疗3例对标准药物治疗难以奏效的慢性GVHD,取得了满意效果。3例接受 BMT 治疗的白血病患者,年龄13～43岁。2例 BMT 时为 CML 缓解期,1例为急性淋巴母细胞白血病(CLL)第三次缓解。预处理方案包括阿糖胞苷、环磷酰胺及全身照射(TBI,12Gy),其中1例还包括 TLI。所有3例均接受环孢霉素及强的松预防急性 GVHD。2例发生急性 GVHD,采用大
Total lymphoid irradiation (TLI), as a method of immunosuppressive therapy, is commonly used in patients with immune disorders and organ transplantations. The authors obtained satisfactory results using TLI in 3 patients with chronic GVHD that is refractory to standard medical therapy. Three patients with leukemia received BMT, aged 13 to 43 years. Two patients had CML remission in BMT and one patient had a third remission in acute lymphoblastic leukemia (CLL). Pretreatment regimens included cytarabine, cyclophosphamide and systemic irradiation (TBI, 12 Gy), of which 1 also included TLI. All 3 patients received cyclosporine and prednisone to prevent acute GVHD. 2 cases of acute GVHD, using large