[目的]检测肺癌患者血清中可溶性疱疹病毒侵入介体(sHVEM)的水平并探讨其临床意义。[方法]应用ELISA夹心法检测86例肺癌和52例正常人血清中sHVEM水平,探讨sHVEM水平的临床意义。[结果]不同分型的肺癌患者组血清sHVEM水平与正常人比较均明显升高,差异有统计学意义(P﹤0.01),且肺癌患者组血清sHVEM水平与分型及恶性程度成正相关,肺鳞癌患者血清sHVEM水平Ⅲ期患者组明显高于Ⅰ/Ⅱ期患者组,肺腺癌术后患者血清sHVEM水平显著低于术前。[结论]肺癌患者组血清sHVEM水平显著增高,且与临床分型、分期和治疗情况呈正相关,提示sHVEM可能与肺癌的发病有关,检测sHVEM对肺癌患者的诊断及疗效评估有一定的意义。 [Objective] To detect the level of soluble herpesvirus RNA (sHVEM) in serum of patients with lung cancer and to explore its clinical significance. [Method] The serum levels of sHVEM in 86 lung cancer patients and 52 normal individuals were detected by ELISA sandwich method. The clinical significance of sHVEM levels was explored. [Results] The serum levels of sHVEM in patients with different types of lung cancer were significantly higher than those in healthy people (P <0.01), and the level of serum sHVEM in lung cancer patients was positively correlated with the type and degree of malignancy Serum levels of sHVEM in patients with stage Ⅲ squamous cell carcinoma were significantly higher than those in stage Ⅰ / Ⅱ patients, and serum levels of sHVEM in patients with squamous cell carcinoma were significantly lower than those before surgery. [Conclusion] The level of serum sHVEM in patients with lung cancer is significantly increased, and it is positively correlated with the clinical classification, staging and treatment, suggesting that sHVEM may be related to the pathogenesis of lung cancer. The detection of sHVEM is of certain significance in the diagnosis and efficacy evaluation of patients with lung cancer.