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目的 观察基层医院重症监护病房住院患者感染病原菌特点及其耐药情况.方法 选择基层医院ICU住院的496例的病原资料,观察其感染率、病原菌分布及耐药性.结果 基层医院ICU医院感染发生率为20.97％,以脑卒中30.80％)和多发伤(18.95％)为主,下呼吸道感染(31.73％)和泌尿系统感染(27.88％)居高.医院感染病原菌以革兰阴性菌(61.90％)为主,革兰阳性菌(30.95％)偏低.革兰阴性菌以大肠埃希菌(16.67％)最多,其次依次为铜绿假单胞菌、克雷伯菌属、鲍曼不动杆菌、阴沟肠杆菌.药敏试验显示革兰阴性菌对含酶抑制剂类的亚胺培南耐药率低,而头孢呋辛、头孢他啶、头孢曲松等耐药率高.革兰阳性菌主要以金黄色葡萄球菌(16.07％)为主,其次为溶血性链球菌、肠球菌等.药敏试验显示革兰阳性菌对万古霉素、替考拉宁、利奈唑胺敏感,未发现对万古霉素、替考拉宁、利奈唑胺耐药菌株.结论 降低院内感染发生率必须加强医院感染相关因素的控制和预防.“,”Objective To observe the features of pathogenic bacteria infection in intensive care unit in a basic hospital and its drug resistance.Methods The pathogenic data of 496 cases of a primary hospital inpatients with ICU,to observe the infection rate,distribution and drug resistance of pathogenic bacteria.Results The infection rate of ICU in the primary hospital was 20.97％,in which,the higher were 30.80％ with stroke and multiple injuries (18.95％),infection of lower respiratory tract infection (31.73％) and urinary tract (27.88 ％).Pathogen of nosocomial infection with Gram negative bacteria was 61.90 ％,gram positive bacteria was 30.95 ％.Gram negative bacteria were Escherichia coli (16.67 ％) as the most,followed by Pseudomonas aeruginosa,Klebsiella,Bauman Acinetobacter,Enterobacter cloacae.Drug sensitivity test showed that gram negative bacteria and low rate of imipenem resistant enzyme inhibitors,and cefuroxime sodium,ceftazidime,ceftriaxone resistant rate.Gram positive bacteria were mainly Staphylococcus aureus (16.07％),followed by hemolytic streptococcus,Enterococcus etc.Drug sensitivity test showed that gram positive bacteria were sensitive to vancomycin,linezolid,Ti Koa Laing,was not found to vancomycin,linezolid resistant strains,Ti Koa Laing.Conclusion To reduce the incidence of the primary hospital,we must strengthen the control and prevention of infection related factors of hospital infection in hospital.