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目的:比较淫羊藿油炙前后及分别组成二仙汤后对肾阳虚小鼠脏器指数、自主活动变化和血清睾酮的影响,探讨生、炙淫羊藿温肾助阳作用的差异。方法:采用氢化可的松所致的肾阳虚小鼠模型,比较淫羊藿油炙前后及分别组成二仙汤后对小鼠脏器指数(睾丸、精囊腺、包皮腺、胸腺)、自主活动变化及血清睾酮变化的影响,分析油炙前后淫羊藿温肾助阳功效的差异。结果:与模型组相比,淫羊藿生品、炙品及二仙汤生品、炙品均具有极显著升高血清睾酮的作用(P<0.01),且炙品升高效果显著强于生品(P<0.05);除模型组外,各组小鼠脏器指数(睾丸、胸腺、包皮腺和精囊腺)和自主活动性均有显著改善(P<0.05~0.01)。结论:淫羊藿油炙前后及分别组成二仙汤后对氢化可的松所致肾阳虚小鼠脏器指数、血清睾酮和自主活动变化均具有较明显改善作用,且淫羊藿油炙后温肾助阳作用强于生品。
Objective: To compare the effect of Epimedium oil Sunburn before and after the composition of Erxian Decoction on kidney-yang mice organ index, changes in serum levels of spontaneous activity and testosterone, explore Epimedium, Sunburn Epimedium Wenshen help Yang difference. Methods: Kidney-yang mice model induced by hydrocortisone was used to compare the changes of organ index (testis, seminal vesicles, preputial gland, thymus), autonomic Activity changes and serum testosterone changes, before and after oil Sunburn Epimedium Wenshen help Yang difference. Results: Compared with the model group, the epimedium, broiled product and Erxiantang raw product and the product with sunburn product all had extremely significant increase of serum testosterone (P <0.01), and the increasing effect of the product was significantly stronger than that of the raw product (P <0.05). Except for the model group, the organ index (testis, thymus, preputial gland and seminal vesicle) and autonomic activity of mice in each group were significantly improved (P <0.05 ~ 0.01). Conclusion: Epimedium Oil Sunburn before and after the composition of Erxian Decoction hydrocortisone-induced kidney yang mice organ index, serum testosterone and spontaneous activity changes have significantly improved, and Epimedium Oil Sunburn After the warm kidney yang role than raw products.