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通过对40例宫颈鳞癌和6例鳞化的宫颈上皮进行AgNOR染色,结果发现宫颈鳞癌与鳞化上皮的AgNOR计数有显著差异(P<0.001),并进一步发现AgNOR计数与宫颈癌的组织形态和细胞学分级有关。同时通过对30例有随访资料的宫颈癌病例的AgNOR计数分析,发现在确诊后三年内死亡的17例和仍存活的13例病人的癌组织AgNOR计数有极显著差异(P< 0.001)。讨论了AgNOR计数作为宫颈鳞癌的一项新的临床病理诊断辅助指标的可能性。
AgNOR staining of squamous cell carcinoma and squamous cell carcinoma of 40 cases of cervical squamous cell carcinoma showed that the AgNOR counts of squamous cell carcinoma and squamous cell carcinoma were significantly different (P <0.001), and further found that AgNOR count and cervical cancer tissue Morphology and cytology grade related. AgNOR count analysis of 30 cases of cervical cancer with follow-up data showed that the AgNOR count of 17 cancer patients survived within 3 years after diagnosis and 13 survivors were significantly different (P <0.001). The possibility of AgNOR counting as a new clinical and pathological diagnostic indicator of cervical squamous cell carcinoma is discussed.