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综述了毛细管电泳(CE)在基因突变分析中的应用及研究进展。主要介绍毛细管电泳-限制性片段长度多态性分析、毛细管电泳-单链构象多态性分析、毛细管电泳-连接酶链法及毛细管电泳-双脱氧链终止法等分析方法。文中指出,因其在基因突变分析中所具有的巨大应用潜力,毛细管电泳将在基因治疗和抗癌药物研究中发挥重要的作用。
The application of capillary electrophoresis (CE) in gene mutation analysis and its research progress are summarized. Mainly introduced capillary electrophoresis - restriction fragment length polymorphism analysis, capillary electrophoresis - single strand conformation polymorphism analysis, capillary electrophoresis - ligase chain analysis and capillary electrophoresis - dideoxy chain termination method. The paper points out that capillary electrophoresis will play an important role in gene therapy and anticancer drug research due to its great potential in gene mutation analysis.