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[目的]探讨黄芪注射液对COPD大鼠血清及肺泡灌洗液中细胞因子的影响。[方法]30只SD大鼠随机分为3组:健康对照组及COPD组分别饲养28d;干预组,d8起每天腹腔注射黄芪注射液250mg.kg-1至d28。通过测定BALF中白细胞总数及百分比,BALF和血清中的IL-8及TNF-α浓度,观察应用黄芪注射液治疗后上述指标的变化。[结果]干预组BALF和血清中IL-8及TNF-α浓度、白细胞总数、中性粒细胞绝对计数、中性粒细胞百分比浓度较正常对照组增高,较COPD组降低,差异有统计学意义(P﹤0.01)。[结论]黄芪注射液可降低COPD大鼠血清及BALF中IL-8及TNF-α水平,并使炎症细胞减少,对COPD大鼠气道炎症具有治疗作用。
[Objective] To investigate the effect of Astragalus injection on cytokines in serum and bronchoalveolar lavage fluid of COPD rats. [Methods] Thirty SD rats were randomly divided into three groups: healthy control group and COPD group were fed for 28 days. In intervention group, intraperitoneal injection of astragalus injection 250mg.kg-1 to d28 daily from d8. By measuring the total number of white blood cells and the percentage of BALF, BALF and serum concentrations of IL-8 and TNF-α, observe the application of Astragalus injection after treatment of the above indicators changes. [Results] The concentrations of IL-8 and TNF-α in BALF and serum, the total number of leucocytes, the absolute neutrophil count and the percentage of neutrophils in BALF and serum in intervention group were higher than those in normal control group and lower than those in COPD group, the difference was statistically significant (P <0.01). [Conclusion] Astragalus injection can reduce the levels of IL-8 and TNF-α in the serum and BALF of COPD rats, reduce the number of inflammatory cells, and have a therapeutic effect on airway inflammation in COPD rats.