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实体肿瘤的持续性生长和转移依赖于血管生成。我们既往研究提示 ,血管内皮生长因子 (ｖａｓｃｕｌａｒｅｎｄｏｔｈｅｌｉａｌｇｒｏｗｔｈｆａｃｔｏｒ ,ＶＥＧＦ)与结肠癌血管生成、转移密切相关[1] 。研究认为 ,抑癌基因 ｐ5 3可能参与血管生成的调节。突变型ｐ5 3可通过激
The persistent growth and metastasis of solid tumors depends on angiogenesis. Our previous studies suggest that vascular endothelial growth factor (VEGF) is closely related to angiogenesis and metastasis of colon cancer [1]. Studies suggest that the tumor suppressor gene p53 may be involved in the regulation of angiogenesis. Mutant p5 3 can be stimulated