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目的了解本院临床分离的肺炎克雷伯菌的耐药表型组合及变迁,为多重耐药的临床抗生素的应用提供理论基础。方法对2012年-2014年所有分离检测到的肺炎克雷伯菌进行菌株鉴定及抗生素敏感试验,用WHONET软件进行统计分析。结果 2012年-2014年临床分离的野生型肺炎克雷伯菌逐年下降,对碳青酶烯酶耐药表型菌株呈逐年升高趋势,所占比率分别为5.10%、9.09%、11.48%。结论肺炎克雷伯菌的耐药情况比较严重;多种耐药机制普遍存在于肺炎克雷伯菌之中,临床应加强监测,关注抗生素耐药性变化与增长趋势。
Objective To understand the clinical phenotypes and changes of Klebsiella pneumoniae isolated from our hospital and provide a theoretical basis for the application of multi-drug resistant clinical antibiotics. Methods All isolates of Klebsiella pneumoniae that were isolated and detected from 2012 to 2014 were tested for their antibiotic sensitivity and susceptibility testing by WHONET software. Results The clinical isolates of Klebsiella pneumoniae from 2012 to 2014 decreased year by year, showing an increasing trend toward carbapenemase resistant phenotype strains, accounting for 5.10%, 9.09% and 11.48%, respectively. Conclusions The Klebsiella pneumoniae is more resistant to the drug. A variety of drug resistance mechanisms are common in Klebsiella pneumoniae. Clinically, the surveillance should be strengthened, and the change of antibiotic resistance and the trend of growth are concerned.