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本实验采用三种测痛阈方法(热板法、电刺激法、扭体法),观察消炎解毒丸对两种动物(大鼠、小鼠)痛阈的影响。小鼠以150mg/kg消炎解毒九灌胃后可使痛阈明显升高,作用持续约3hr;以75mg/kg消炎解毒丸腹腔注射30min左右,可使痛阈明显升高,至1hr测定时,作用已消失。大鼠以消炎解毒丸75mg/kg腹腔注射30min也可使痛阈升高,剂量大至150mg/kg时,则痛阈升高更为明显,作用可持续3.5hr以上。此外,小鼠以18.75mg/kg、37.50mg/kg、75mg/kg的消炎解毒九腹腔注射后,用扭体法测定均显示镇痛效果,其强度与剂量成正比。
In this experiment, three methods for measuring pain threshold (hot plate method, electrical stimulation method, and writhing method) were used to observe the effect of Xiaoyan Jiedu Pills on the pain threshold of two animals (rats and mice). After the mice were treated with 150mg/kg anti-inflammatory, detoxification, the pain threshold was significantly increased, and the effect lasted for about 3 hours. When the 75mg/kg anti-inflammatory and detoxification pills were injected intraperitoneally for about 30 minutes, the pain threshold was significantly increased, and the pain threshold was increased to 1hr. The role has disappeared. Rats can increase the pain threshold by intraperitoneal injection of 75mg/kg of Xiaoyanjiedu pill for 30min. When the dose is 150mg/kg, the pain threshold is more obvious, and the effect lasts for more than 3.5hr. In addition, after the mice were injected with 18.75mg/kg, 37.50mg/kg, and 75mg/kg of anti-inflammatory and detoxification drugs, the analgesic effect was measured by the writhing method. The strength was proportional to the dose.