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背景:近些年来,静电纺丝材料正在临床载药领域得到越来越广泛的应用。目的:综述静电纺丝材料在载药系统中的应用及其前景。方法:以“Electrospinning,drug delivery system,nanofibers,electrospun materials”为关键词,检索Pub Med、NCBI数据库中近10年来关于载药电纺支架在组织工程、肿瘤化疗等临床应用领域的最新进展。结果与结论:与传统材料相比,静电纺丝支架具有良好的多样性及参数高可控性,在针对不同组织生理条件下的个性化应用具有独到优势。目前相关载药材料主要由天然产物、合成高分子材料及混纺材料等构成,搭载药物主要包括抗生素、化疗药、蛋白质及DNA等。静电纺丝材料在临床主要应用于组织工程、肿瘤化疗、创面愈合等领域,如何实现药物在多聚物溶液中的稳定均一扩散的同时保证高载药率及低药物流失是最终的目标。相信电纺材料以其固有优势配合多样化的载药方案,必将在这一交叉学科中获得更大的发展。
Background: In recent years, electrospun materials are getting more and more widely used in the field of clinical medicine. Objective: To summarize the application and prospects of electrospun materials in drug delivery system. Methods: The recent advances in the clinical application of drug-loaded electrospun scaffolds in tissue engineering and oncology and chemotherapy in the PubMed and NCBI databases over the past 10 years were searched with the keywords “Electrospinning, drug delivery system, nanofibers, electrospun materials” . RESULTS AND CONCLUSION: Compared with the traditional materials, the electrospun scaffold has a good diversity and high controllability of parameters, and has unique advantages in individualized application under different physiological conditions. At present, the related drug-loaded materials are mainly composed of natural products, synthetic polymer materials and blended materials, and the drugs mainly include antibiotics, chemotherapy drugs, proteins and DNA. Electrospun materials are mainly used in the fields of tissue engineering, tumor chemotherapy and wound healing in clinical practice. How to achieve stable and uniform diffusion of drugs in polymer solution while ensuring high drug loading rate and low drug loss is the ultimate goal. I believe that with its inherent advantages of electrospun materials with a variety of drug-loaded programs, is bound to get more development in this interdisciplinary.