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目的 探讨七氟烷和丙泊酚麻醉对老年肺癌患者肌酸磷酸激酶同工酶 (CK -MB)、心肌肌钙蛋白I (cTnI) 和皮质醇 (COR) 的影响.方法 按照随机数字表法将88例老年肺癌患者平均分为研究组和对照组,两组患者均选择咪达唑仑、罗库溴铵及依托咪酯等静脉诱导麻醉,研究组患者行七氟烷持续吸入麻醉,对照组患者行丙泊酚持续静注麻醉,比较两组患者不同时间点 CK -MB、cTnI 和 COR水平.结果 两组患者在T2、T3、T4、T5时的cTnI、COR含量均显著高于同组T1时,在T3、T4、T5时的CK-MB含量均显著高于同组T1时,差异有统计学意义 (P <0.05);研究组在T2、T3、T4、T5时的cTnI含量显著低于对照组,在T4、T5时的CK-MB含量显著低于对照组,在T2、T3、T4时的COR含量显著低于对照组,差异有统计学意义 (P<0.05).结论 七氟烷吸入麻醉在老年肺癌患者手术治疗中对患者心肌损伤较小,值得临床应用与推广.“,”Objective To analyze the effect of propofol and sevoflurane on cardiac troponin I, creatine kinase isoenzyme (CK-MB) and cortisol (COR) in the elderly patients with lung cancer. Methods 88 Patients with lung cancer were randomly di-vided into the study group and the control group. All the patients were introvenous induction by midazolam, rocuronium, etomidate and so on. The study group underwent continuous sevoflurane inhalation anesthesia and the control group underwent propofol intrave-nous anesthesia. The levels of cTnI, CK-MB and COR at different time points were observed. Results The levels of cTnI and COR at T2, T3, T4, T5 were higher than those at T1 in the two groups (P<0.05). The levels of CK-MB at T3, T4, T5 were higher than those at T1 in the two groups (P<0.05). The levels of cTnI at T2, T3, T4, T5 in the study group was lower than those in the control group (P<0.05). The levels of CK-MB at T4, T5 in the study group were lower than those in the control group (P<0.05). The levels of COR at T2, T3, T4 in the study group were lower than those in the control group (P<0.05). Conclusion Sevoflurane inhalation anesthesia has little myocardial injury in the elderly patients with lung cancer.