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目的研究运动对MS大鼠炎症状态和应激水平的影响,探讨长期规律运动对MS的作用及对急性运动刺激的适应,为MS的运动康复提供理论参考。方法 50只SD雄性大鼠随机分为空白对照组(CG)和实验组(EG),EG大鼠采用高果糖膳食诱导MS模型,将部分MS大鼠随机分为安静组(RG)、安静与急性运动组(REG)、运动组(TG)和长期运动与急性运动组(TEG),每组8只,TG跑台运动14周,每周5 d,每天运动25 cm/s,35 min,急性运动一次35 cm/s,35 min,运动后标准方法检测大鼠血Glu,ELISA检测FINS、IL-6、CRP和CTC水平,高效液相荧光法测定NE浓度。结果膳食诱导大鼠MS模型成功;与CG相比,RG和TG大鼠血Glu、IL-6、CPR和NE水平均显著升高(P<0.01,P<0.001,P<0.001,P<0.001);与RG相比,TG大鼠血Glu、IL-6、CRP和NE水平均显著升高(P<0.05,P<0.01,P<0.01,P<0.001),但CTC水平显著降低(P<0.05);急性运动使RG大鼠IL-6、CPR和NE水平显著升高(P<0.001,P<0.05,P<0.01),而对TG大鼠无显著影响;TG大鼠在一次急性运动后CTC水平显著升高(P<0.05)。结论 (1)MS大鼠出现炎症-应激反馈机制失衡,从而诱导全身低度炎症和/或代谢性高血糖;(2)不恰当的运动会增强MS大鼠炎症水平和应激状态,诱导更多的糖原释放入血,进而加剧MS相关代谢、炎症和应激紊乱;(3)长期规律运动MS大鼠进行急性运动刺激后炎症反应降低,机体产生抗炎性适应。
Objective To study the effects of exercise on the inflammatory state and stress level in MS rats and to explore the effect of long-term regular exercise on MS and its adaptation to acute motor stimulation to provide theoretical reference for the rehabilitation of MS. Methods Fifty SD male rats were randomly divided into blank control group (CG) and experimental group (EG). EG rats were induced by high fructose diet. MS rats were randomly divided into quiet group (RG) Acute exercise group (REG), exercise group (TG), and long-term exercise and acute exercise group (TEG), each group had 8 rats, TG treadmill exercise for 14 weeks, Acute exercise 35 cm / s, 35 min, after exercise, blood Glu levels were measured by standard methods. FINS, IL-6, CRP and CTC levels were measured by ELISA. NE concentration was measured by high performance liquid chromatography. Results Compared with CG, the levels of Glu, IL-6, CPR and NE in RG and TG rats were significantly increased (P <0.01, P <0.001, P <0.001, P <0.001 ). Compared with RG, the levels of Glu, IL-6, CRP and NE in TG rats were significantly increased (P <0.05, P <0.01, P < <0.05). Acute exercise increased the levels of IL-6, CPR and NE in RG rats (P <0.001, P <0.05, P <0.01), but had no significant effect on TG rats. CTC levels increased significantly after exercise (P <0.05). Conclusions (1) MS rats exhibit an imbalance of inflammation-stress feedback mechanism and thus induce systemic low-grade inflammation and / or metabolic hyperglycemia; (2) inappropriate exercise can increase inflammation and stress status in MS rats and induce more More glycogen released into the blood, thereby exacerbating MS-related metabolism, inflammation and stress disorders; (3) long-term regular exercise MS rats after acute exercise to reduce the inflammatory response, the body produces anti-inflammatory adaptation.