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目的探讨他莫昔芬对大鼠蛛网膜下腔出血(SAH)后早期脑损伤的神经保护作用。方法 60只健康成年雄性SD大鼠随机均分为四组:对照(BC)组、SAH(MC)组、安慰剂(VC)组和他莫昔芬治疗(TT)组。应用视交叉前池一次注血法制成SAH后早期脑损伤模型,在SAH后2、24及36h分别腹腔注射他莫昔芬;48h后处死大鼠,取颞底皮层脑组织做标本,测定脑水肿指数及血脑屏障变化。结果与BC组相比,MC组大鼠脑组织含水量明显增加,血脑屏障破坏明显;与MC组相比,TT组脑水肿指数降低,血脑屏障功能改善。结论他莫昔芬能有效降低SAH后脑水肿、改善血脑屏障,提示他莫昔芬对大鼠SAH后早期脑损伤具有神经保护作用。
Objective To investigate the neuroprotective effect of tamoxifen on early brain injury after subarachnoid hemorrhage (SAH) in rats. Methods Sixty healthy adult male Sprague-Dawley rats were randomly divided into four groups: control (BC) group, SAH (MC) group, placebo group and tamoxifen treatment group. The rat model of early brain injury after SAH was made by one injection of the optic chiasm in the forebrain. Tamoxifen was intraperitoneally injected at 2, 24, and 36 hours after SAH, respectively. After 48 hours, the rats were sacrificed and the brain tissue of the temporal cortex was taken as the specimens. Edema index and blood-brain barrier changes. Results Compared with BC group, the water content of brain tissue in MC group increased significantly, and the blood-brain barrier disrupted obviously. Compared with MC group, the brain edema index of TT group decreased and the function of blood-brain barrier improved. Conclusion Tamoxifen can effectively reduce cerebral edema and improve the blood-brain barrier after SAH, indicating that tamoxifen has neuroprotective effect on early brain injury after SAH in rats.