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目的观察丹参酮ⅡA对局灶性脑缺血再灌注大鼠的保护作用。方法采用线栓法制备大鼠局灶性脑缺血再灌注模型,缺血前大鼠灌胃给药7天,观察丹参酮ⅡA对手术大鼠的行为学得分、脑含水量、脑梗塞率、脑指数、血小板聚集率、血液流变性、血浆血栓素、前列环素和内皮素的影响。结果丹参酮ⅡA30mg/kg、15mg/kg可明显降低手术大鼠的行为学得分,降低脑含水量和脑梗塞率,可以改善试验动物的血液流变性,降低血小板聚集率。结论丹参酮ⅡA对局灶性脑缺血再灌注大鼠具有保护作用。
Objective To observe the protective effect of tanshinone ⅡA on focal cerebral ischemia-reperfusion in rats. Methods The rat model of focal cerebral ischemia-reperfusion was established by thread occlusion. The rats were administered intragastrically for 7 days before tanshinone ⅡA. The behavioral scores, brain water content, cerebral infarction rate, Brain index, platelet aggregation rate, hemorrheology, plasma thromboxane, prostacyclin and endothelin. Results Tanshinone Ⅱ A 30mg / kg, 15mg / kg can significantly reduce the behavioral score of rats, reduce brain water content and cerebral infarction rate, can improve the blood rheology of experimental animals and reduce the rate of platelet aggregation. Conclusion Tanshinone ⅡA has a protective effect on focal cerebral ischemia-reperfusion in rats.