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[目的]探讨细胞色素氧化酶基因 (CYP1A1)和谷胱甘肽转硫酶基因(GSTM1)多态性与胃癌和萎缩性胃炎等胃部疾病易感性的关系。[方法]对病理诊断的胃癌 (GC)102例、慢性萎缩性胃炎(CAG)110例、胃溃疡(GU)62例、慢性浅表性胃炎(CSG)103例、十二指肠溃疡(DU)62例、正常人62例的CYP1A1和GSTM1基因型采用序列特异性引物的聚合酶链反应(PCR SSP)方法进行测定,关联度分析采用病例对照研究方法。[结果]非条件Logistic回归在调整年龄、性别、文化程度和职业4个因素后,GC、CAG和GU与CYP1A1G/G、GSTM10/0基因型、幽门螺杆菌 (Hp)感染及吸烟有关联 ,同时基因型间存在明显的交互作用。没有发现DU和CSG与CYP1A1和GSTM1基因型有关联 ,但DU与幽门螺杆菌 (Hp)感染有关联 ,而且Hp感染、吸烟与CYP1A1G/G型之间存在交互作用。[结论]CYP1A1G/G、GSTM10/0基因型与GC、CAG、GU的易感性有关联 ,两个基因型之间及它们各自与Hp感染及吸烟之间有交互作用。
[Objective] To investigate the relationship between CYP1A1 and GSTM1 polymorphisms and gastric diseases such as gastric cancer and atrophic gastritis. [Method] 102 cases of pathological diagnosis of gastric cancer (GC), 110 cases of chronic atrophic gastritis (CAG), 62 cases of gastric ulcer (GU), 103 cases of chronic superficial gastritis (CSG), 103 cases of duodenal ulcer ) 62 cases, normal 62 cases of CYP1A1 and GSTM1 genotypes using sequence-specific primers polymerase chain reaction (PCR SSP) method for the determination of correlation analysis using case-control study. [Result] GC / CAG and GU were associated with CYP1A1G / G, GSTM10 / 0 genotypes, Hp infection and smoking after adjusting for age, sex, education level and occupation. At the same time there is a significant interaction between genotypes. DU and CSG were not found to be associated with the CYP1A1 and GSTM1 genotypes, but DU was associated with H. pylori (Hp) infection and there was an interaction between H. pylori infection and smoking and the CYP1A1G / G genotype. [Conclusion] The genotypes of CYP1A1G / G and GSTM10 / 0 are associated with susceptibility to GC, CAG and GU, and there is interaction between the two genotypes and between them and Hp infection and smoking.