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目的检测类风湿关节炎(RA)患者的富含半胱氨酸蛋白61(cysteine-rich 61,Cyr61)水平,比较不同病程患者的血清Cyr61水平,对患者血清Cyr61水平与各相关指标进行分析。方法 ELISA方法检测RA与健康对照组的血清Cyr61水平。结果 RA的血清Cyr61水平高于健康对照组(P<0.01),早期RA的血清Cyr61水平高于中晚期患者(P<0.05),RA的血清Cyr61水平与类风湿因子(RF)水平正相关(r=0.362,P<0.05)。结论 Cyr61可能参与RA的发病机制,水平升高可能预示RA预后不佳。
Objective To detect the serum levels of Cyr61 in patients with rheumatoid arthritis (RA) and to compare serum Cyr61 levels in patients with different stages of disease and to analyze the serum Cyr61 levels and related indicators. Methods Serum Cyr61 levels in RA and healthy controls were measured by ELISA. Results Serum levels of Cyr61 in RA were significantly higher than those in healthy controls (P <0.01). Serum levels of Cyr61 in early RA were higher than those in advanced stage (P <0.05), while serum Cyr61 levels in RA were positively correlated with rheumatoid factor (RF) r = 0.362, P <0.05). Conclusions Cyr61 may be involved in the pathogenesis of RA. Elevated levels may indicate poor prognosis of RA.