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我国药典收载之桔梗为桔梗科植物Platycdongrandiflorum A、DC.,药用其根。吉林省东部山区,产有上述桔梗的一变种——白花桔梗Platyc-odon grandiflorum A.DC.Var.album Hort。两者区别在于前者为紫色花,后者白色。本文研究此白花桔梗是否同样具有紫花桔梗的主要药理作用。一、祛痰实验:小鼠灌胃给药后45分钟,开始测定其呼吸道灌洗液的酚红浓度。结果表明,白花与紫花桔梗皂甙均有明显祛痰作用。二、镇咳实验:小鼠服药后45分钟,开始采用“上下法”测算每组动物之半数有效量(ED_(50))。以对照组小鼠引起半数咳嗽所需时间为100%,给药组与其比较,在130%以上者为“有效”结果表明,两种桔梗组均呈现明显的镇咳作用。三、镇痛实验:
The Chinese platycodons included in the Chinese Pharmacopoeia are Platycdongrandiflorum A and DC. They are medicinal roots. In the eastern mountainous region of Jilin Province, there is a variant of the above-mentioned Platycodon grandiflorum Platyc-odon grandiflorum A.DC.Var.album Hort. The difference between the two is that the former is purple and the latter is white. This article studies whether this white flower has the main pharmacological effects of P. orientalis. First, sputum test: 45 minutes after oral administration of mice, the phenol red concentration of the respiratory lavage fluid was measured. The results showed that both the white flower and the saponin of S. platycodonis had significant scorpion effect. Second, the antitussive test: 45 minutes after taking the mice, began to use the “up and down method” to measure the effective half of each group of animals (ED_ (50)). The time required for half of the cough caused by mice in the control group was 100%. Compared with the drug-administered group, more than 130% of the mice in the control group were “effective”. The results showed that both of the Campanulaceae groups showed significant antitussive effect. Third, analgesic experiments: